PROBENECID |
|
PROBENECID
BRAND & GENERIC NAMES
Benacen
Benemid
Benuryl
ColBENEMID
Col-Probenecid
Polycillin-PRB
Probalan
SK-Probenecid
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antigout (uricosuric)
USES
Treatment for chronic gout.
Increases blood levels of penicillins and cephalosporins.
DOSAGE & USAGE INFORMATION
How to take:
Tablet -- Swallow with liquid or food to lessen stomach
irritation. If you can't swallow whole, crumble tablet and take
with liquid or food.
When to take:
At the same time each day.
If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than
12 hours, wait for next scheduled dose (don't double this dose).
What drug does:
Forces kidneys to excrete uric acid.
Reduces amount of penicillin excreted in urine, so increases
blood level.
Time lapse before drug works:
May require several months of regular use to prevent acute gout.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Breathing difficulty, severe nervous agitation, vomiting,
seizures, convulsions, delirium, coma.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
None expected.
Common:
Headache, appetite Continue. Call doctor
loss, nausea, when convenient.
vomiting.
Infrequent:
Blood in urine, Discontinue. Call
low back pain. doctor right away.
worsening gout.
Dizziness, flushed Continue. Call doctor
face, itchy skin. when convenient.
Painful or frequent Continue. Tell doctor
urination. at next visit.
Rare:
Sore throat; difficult Discontinue. Call
breathing; unusual doctor right away.
bleeding or bruising;
red, painful joint;
jaundice; fever.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to any uricosuric.
You have acute gout.
Patient is younger than 2.
Before you start, consult your doctor:
If you have had kidney stones or kidney disease.
If you have a peptic ulcer.
If you have bone-marrow or blood-cell disease.
Pregnancy:
Studies inconclusive on harm to unborn child. Animal studies
show fetal abnormalities. Decide with your doctor whether drug
benefits justify risk to unborn child.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
Possible kidney damage.
Skin & sunlight:
No age-related problems expected.
Driving or hazardous activities:
Avoid if you feel dizzy. Otherwise, no problems expected.
Discontinuing:
Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
Others:
If signs of gout attack develop while taking medicine, consult
doctor.
POSSIBLE INTERACTION WITH OTHER DRUGS
|
|
|
| Allopurinol |
Increased effect of each drug. |
| Anticoagulants (oral, |
Increased |
| see Drugs Glossary) |
anticoagulant effect. |
| Aspirin |
Decreased probenecid effect. |
| Cephalosporins |
Increased cephalosporin effect. |
| (see Drugs Glossary) |
| Dapsone |
Increased dapsone effect. Increased |
| |
toxicity. |
| Diuretics (thiazide, |
Decreased |
| see Drugs Glossary) |
probenecid effect. |
| Hypoglycemics (oral, |
Increased |
| see Drugs Glossary) |
hypoglycemic effect. |
| Indomethacin |
Increased adverse effects of |
| |
indomethacin. |
| Methotrexate |
Increased methotrexate toxicity. |
| Nitrofurantoin |
Incresed effect of nitrofurantoin. |
| Para-aminosalicylic |
Increased effect of acid (PAS)para- |
| |
aminosalicylic acid. |
| Penicillins |
Enhanced penicillin effect. |
| (see Drugs Glossary) |
| Pyrazinamide |
Decreased probenecid effect. |
| Salicylates |
Decreased probenecid effect. |
| (see Drugs Glossary) |
| Sulfa drugs |
Slows elimination. |
| |
May cause harmful accumulation of |
| |
sulfa. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
|
|
|
| Tobacco: |
None expected. |
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