NITRATES |
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NITRATES
BRAND & GENERIC NAMES
AMYL NITRITE Nitroglyn
Ang-O-Span Nitrol
Apo-ISDN Nitrolin
Cardilate Nitrolingual
Coronex Nitro-Long
Deponit Nitronet
Dilatrate SR Nitrong
Duotrate Nitrong SR
ERYTHRITYL Nitrospan
TETRANITRATE Nitrostabilin
Iso-Bid Nitrostat
Isochron Nitro-Time
Isonate Novosorbide
Isonate TR NTS
Isordil Onset
ISOSORBIDE DINITRATE PENTAERYTHRITOL
Isotrate TETRANITRATE
Klavikordal Pentol
Naptrate Pentol S.A.
N-G-C Pentraspan SR
Niong Pentritol
Nitro-Bid Pentylan
Nitrobon Peritrate
Nitrocap Peritrate Forte
Nitrocap T.D. Peritrate SA
Nitrocardin Sorate
Nitrodisc Sorbide T.D.
Nitro-Dir Sorbitrate
Nitro-Dur II Sorbitrate SA
Nitrogard Transderm-Nitro
Nitrogard SR Tridil
NITROGLYCERIN
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antianginal (nitrate)
USES
Reduces frequency and severity of angina attacks.
Treats congestive heart failure.
DOSAGE & USAGE INFORMATION
How to take:
Extended-release tablets or capsules-- Swallow each dose whole
with liquid.
Chewable tablet--Chew tablet at earliest sign of angina, and
hold in mouth for 2 minutes.
Regular tablet or capsule--Swallow whole with liquid. Don't
crush, chew or open.
Buccal tablets (Nitrogard)--Allow to dissolve in side of mouth.
Translingual spray (nitrolingual)--Spray under tongue according
to instructions enclosed with prescription.
Ointment--Apply as directed.
Patches--Apply to skin according to package instructions.
Sublingual tablets--Place under tongue every 3 to 5 minutes at
earliest sign of angina. If you don't have complete relief with
3 or 4 tablets, call doctor.
When to take:
Swallowed tablets--Take at the same times each day, 1 or 2
hours after meals.
Sublingual tablets or spray--At onset of angina.
Ointment--Follow prescription directions.
Patches--According to physician's instructions.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Relaxes blood vessels, increasing blood flow to heart muscle.
Time lapse before drug works:
Sublingual tablets and spray--1 to 3 minutes.
Other forms--15 to 30 minutes. Will not stop an attack, but may
prevent attacks.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Dizziness; blue fingernails and lips; fainting; shortness of
breath; weak, fast heartbeat; convulsions.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
None expected.
Common:
Headache, flushed Continue. Tell doctor
face and neck, at next visit.
dry mouth, nausea,
vomiting, rapid heartbeat.
Infrequent:
Fainting. Discontinue. Call doctor right
away.
Restlessness, Continue. Call doctor
blurred vision. when convenient.
Rare:
Rash. Discontinue. Call doctor right
away.
Severe irritation, Continue. Call doctor
peeling. when convenient.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to nitrates, including nitroglycerin.
Before you start, consult your doctor:
If you are taking non-prescription drugs.
If you plan to become pregnant within medication period.
If you have glaucoma.
If you have reacted badly to any vasodilator drug.
If you drink alcoholic beverages or smoke marijuana.
Pregnancy:
No proven harm to unborn child. Avoid if possible.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
Drug may become less effective and require higher doses.
Skin & sunlight:
No age-related problems expected.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you drink
alcohol or take medicine affecting alertness and reflexes.
Discontinuing:
Except for sublingual tablets, don't discontinue without
doctor's advice until you complete prescribed dose, even though
symptoms diminish or disappear.
Others:
If discomfort is not caused by angina, nitrate medication will
not bring relief. Call doctor if discomfort persists.
Periodic urine and laboratory blood studies of white cell
counts recommended if you take nitrates.
Keep sublingual tablets in original container. Always carry
them with you, but keep from body heat if possible.
Sublingual tablets produce a burning, stinging sensation when
placed under the tongue. Replace supply if no burning or
stinging is noted.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Anticholinergics |
Increased internal-eye |
| (see Drugs Glossary) |
pressure. |
| Antidepressants, |
Excessive blood- |
| tricyclic (TCA, |
pressure drop. |
| see Drugs Glossary) |
| Antihypertensives |
Excessive blood- |
| (see Drugs Glossary) |
pressure drop. |
| Beta-adrenergic |
Excessive blood- |
| blockers (see |
pressure drop. |
| Drugs Glossary) |
| Calcium channel |
Decreased blood |
| blockers (see |
pressure. |
| Drugs Glossary) |
| Cholinergics |
Decreased cholinergic |
| (see Drugs Glossary) |
effect. |
| Ephedrine |
Decreased nitrate effect. |
| Guanfacine |
Increased effect of both drugs. |
| Narcotics |
Excessive blood- |
| (see Drugs Glossary) |
pressure drop. |
| Phenothiazines |
May decrease blood |
| (see Drugs Glossary) |
pressure. |
| Sympathomimetics |
Possible reduced |
| (see Drugs Glossary) |
effects of both medicines. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
Decreased nitrate effect. |
| Tobacco: |
Decreased nitrate effect. |
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