METOCLOPRAMIDE |
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METOCLOPRAMIDE
BRAND & GENERIC NAMES
Clopra
Emex
Maxeran
Maxolon
Reclomide
Reglan
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antiemetic; dopaminergic
blocker (see Drugs Glossary)
USES
Relieves nausea and vomiting caused by chemotherapy and drug
related postoperative factors.
Relieves symptoms of esophagitis and stomach swelling in people
with diabetes.
DOSAGE & USAGE INFORMATION
How to take:
Tablet or syrup -- Swallow with liquid or food to lessen stomach
irritation.
When to take:
30 minutes before symptoms expected, up to 4 times a day.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Prevents smooth muscle in stomach from relaxing.
Affects vomiting center in brain.
Time lapse before drug works:
30 to 60 minutes.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Severe drowsiness, mental confusion, trembling, seizure, coma.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If the child is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make the child
vomit. If you can't get help quickly, take the child to nearest
emergency facility.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
None expected.
Common:
Drowsiness, Continue. Call doctor
restlessness. when convenient.
Rash. Continue. Call doctor when
convenient.
Infrequent:
Wheezing,
shortness Discontinue. Call
of breath. doctor right away.
Dizziness; headache; Continue. Call doctor
insomnia; tender, when convenient.
swollen breasts;
increased milk flow.
Rare:
Abnormal, involuntary Discontinue. Call
movements of jaw, doctor right away.
lips and tongue;
depression; Parkinson
syndrome.
Constipation, diarrhea, Continue. Call doctor
nausea. when convenient.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to procaine, procainamide or metoclopramide.
Before you start, consult your doctor:
If you have Parkinson's disease.
If you have liver or kidney disease.
If you have epilepsy.
If you have bleeding from gastrointestinal tract or intestinal
obstruction.
If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Pregnancy:
No proven harm to unborn child. Avoid if possible.
Infants & children:
Adverse reactions more likely to occur than in adults.
Prolonged use:
Adverse reactions including muscle spasms and trembling hands
more likely to occur.
Skin & sunlight:
No age-related problems expected.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you drink
alcohol or take medicine affecting alertness and reflexes,
such as antihistamines, tranquilizers, sedatives,
pain medicine, narcotics and mind-altering drugs.
Discontinuing:
May be unnecessary to finish medicine. Follow doctor's
instructions.
Others:
No age-related problems expected.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Acetaminophen |
Increased absorption of |
| |
acetaminophen. |
| Anticholinergics |
Decreased |
| (see Drugs Glossary) |
metoclopramide effect. |
| Aspirin |
Increased absorption of aspirin. |
| Bromocriptine |
Decreased bromocriptine effect. |
| Butyophenone |
Increased chance of muscle spasm |
| |
and trembling. |
| Central nervous |
Excess sedation. |
| system depressants |
| (see Drugs Glossary) |
| Digitalis preparations |
Decreased absorption |
| (see Drugs Glossary) |
of digitalis. |
| Ethinamate |
Dangerous increased effects of |
| |
ethinamate. Avoid combining. |
| Fluoxetine |
Increased depressant effects of |
| |
both drugs. |
| Guanfacine |
May increase depressant effects of |
| |
either drug. |
| Insulin |
Unpredictable changes in blood |
| |
glucose. Dosages may require |
| |
adjustment. |
| Leucovorin |
High alcohol content of leucovorin |
| |
may cause adverse effects. |
| Levodopa |
Increased absorption of levodopa. |
| Lithium |
Increased absorption of lithium. |
| Loxapine |
May increase toxic effects of both |
| |
drugs. |
| Methyprylon |
Increased sedative effect, perhaps |
| |
to dangerous level. Avoid. |
| Narcotics |
Decreased |
| (see Drugs Glossary) |
metoclopramide effect. |
| Phenothiazines |
Increased chance of muscle spasm |
| |
and trembling. |
| Tetracycline |
Slow stomach emptying. |
| Thiothixines |
Increased chance of |
| (see Drugs Glossary) |
muscle spasm and trembling. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
Decreased metoclopramide effect. |
| Tobacco: |
Decreased metoclopramide effect. |
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