DIPHENOXYLATE & ATROPINE |
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DIPHENOXYLATE & ATROPINE
BRAND & GENERIC NAMES
Colonil
Diphenatol
Enoxa
Latropine
Lofene
Lomanate
Lomotil
Lonox
Lo-Trol
Low-Quel
Nor-Mil
SK-Diphenoxylate
BASIC INFORMATION
Habit forming? Yes
Prescription needed? Yes
Available as generic? Yes
Drug class: Antidiarrheal
USES
Relieves diarrhea and intestinal cramps.
DOSAGE & USAGE INFORMATION
How to take:
Tablet--Swallow with liquid or food to lessen stomach
irritation.
Drops or liquid--Follow label instructions and use marked
dropper.
When to take:
No more often than directed on label.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Blocks digestive tract's nerve supply, which reduces propelling
movements.
Time lapse before drug works:
May require 12 to 24 hours of regular doses to control diarrhea,
but cramps usually improve in 30 to 90 minutes.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Excitement, constricted pupils, shallow breathing, coma.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If the child is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make the child
vomit. If you can't get help quickly, take the child to nearest
emergency facility.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
Hives, rash, intense Seek emergency
itching, faintness treatment immediately.
soon after a dose
(anaphylaxis).
Common:
None expected.
Infrequent:
Dry mouth, swollen Discontinue. Call
gums, rapid doctor right away.
heartbeat.
Dizziness, Continue. Call doctor
depression, when convenient.
drowsiness, rash or
itch, blurred vision,
decreased urination.
Rare:
Restlessness, flush, Discontinue. Call
fever, headache, doctor right away.
stomach pain,
nausea, vomiting,
bloating, constipation,
numbness of hands or feet.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to diphenoxylate and atropine or any narcotic
or anticholinergic.
You have jaundice.
You have infectious diarrhea or antibiotic-associated diarrhea.
Patient is younger than 2.
Before you start, consult your doctor:
If you have had liver problems.
If you have ulcerative colitis.
If you plan to become pregnant within medication period.
If you have any medical disorder.
If you take any medication, including non-prescription drugs.
Pregnancy:
No proven harm to unborn child. Avoid because of many side
effects.
Infants & children:
Don't give to infants or toddlers. Use only under doctor's
supervision for children older than 2.
Prolonged use:
Habit forming.
Skin & sunlight:
No age-related problems expected.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you drink
alcohol or take medicine affecting alertness and reflexes.
Discontinuing:
May be unnecessary to finish medicine. Follow doctor's
instructions.
After discontinuing, consult doctor if you experience muscle
cramps, nausea, vomiting, trembling, stomach cramps or unusual
sweating.
Others:
If diarrhea lasts longer than 4 days, discontinue and call
doctor.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Barbiturates |
Increased effect of both drugs. |
| Ethinamate |
Dangerous increased effects of |
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ethinamate. Avoid combining. |
| Fluoxetine |
Increased depressant effects of |
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both drugs. |
| Guanfacine |
May increase depressant effects of |
| |
either drug. |
| Leucovorin |
High alcohol content of leucovorin |
| |
may cause adverse effects. |
| MAO inhibitors |
May increase blood |
| (see Drugs Glossary) |
pressure excessively. |
| Methyprylon |
Increased sedative effect, perhaps |
| |
to dangerous level. Avoid. |
| Sedatives |
Increased effect of both drugs. |
| Tranquilizers |
Increased effect of both drugs. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
None expected. |
| Tobacco: |
None expected. |
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