BETA-ADRENERGIC BLOCKING AGENTS & THIAZIDE DIURETICS |
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BETA-ADRENERGIC BLOCKING AGENTS & THIAZIDE DIURETICS
BRAND & GENERIC NAMES
ATENOLOL & CHLORTHALIDONE Co-Betaloc
Corzide
Inderide
Inderide LA
Lopressor HCT
METOPROLOL & HYDROCHLOROTHIAZIDE
NADOLOL & BENDROFLUMETHIAZIDE
Normozide
PINDOLOL & HYDROCHLOROTHIAZIDE
PROPRANOLOL & HYDROCHLOROTHIAZIDE
Tenoretic
Timolide
TIMOLOL & HYDROCHLOROTHIAZIDE
Trandate HCT
Viskazide
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Beta-adrenergic blocker,
thiazide diuretic
USES
Controls, but doesn't cure, high blood pressure.
Reduces fluid retention (edema).
Reduces angina attacks.
Stabilizes irregular heartbeat.
Lowers blood pressure.
Reduces frequency of migraine headaches. (Does not relieve
headache pain.)
Other uses prescribed by your doctor.
DOSAGE & USAGE INFORMATION
How to take:
Extended-release capsules -- Swallow with liquid. If you can't
swallow whole, crumble tablet and take with liquid or food.
When to take:
At the same time each day.
If you forget a dose:
Take as soon as you remember up to 4 hours late. If more than 4
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Forces sodium and water excretion, reducing body fluid.
Relaxes muscle cells of small arteries.
Reduced body fluid and relaxed arteries lower blood pressure.
Blocks some of the actions of sympathetic nervous system.
Lowers heart's oxygen requirements.
Slows nerve impulses through heart.
Reduces blood vessel contraction in heart, scalp and other body
parts.
Time lapse before drug works:
1 to 4 hours for beta-blocker effect.
May require several weeks to lower blood pressure.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Irregular heartbeat (usually too slow), confusion, fainting,
convulsions, coma.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
Wheezing, chest pain, Seek emergency
irregular heartbeat. treatment immediately.
Common:
Dry mouth, weak Discontinue. Call
pulse, vomiting, doctor right away.
muscle cramps,
increased thirst,
mood changes.
Weakness, tiredness, Continue. Call doctor
dizziness, mental when convenient.
depression, diminished
sex drive, constipation,
nightmares, insomnia.
Infrequent:
Cold feet and hands, Discontinue. Call
chest pain, breathing doctor right away.
difficulty, anxiety,
nervousness, headache,
appetite loss,
abdominal pain, numbness
and tingling in fingers
and toes.
Rare:
Hives, skin rash; Discontinue. Call
joint pain; jaundice; doctor right away.
fever, sore throat,
mouth ulcers.
Impotence. Continue. Call doctor when
convenient.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to any beta-adrenergic blocker or any thiazide
diuretic drug.
You have asthma or hay fever symptoms.
You have taken MAO inhibitors in past two weeks.
Before you start, consult your doctor:
If you have heart disease or poor circulation to the
extremities.
If you have hay fever, asthma, chronic bronchitis, emphysema,
overactive thyroid function, impaired liver or kidney function,
gout, diabetes, hypoglycemia, pancreas disorder, systemic lupus
erythematosus.
If you are allergic to any sulfa drug or tartrazine dye.
If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
Weakens heart muscle contractions.
You may need medicine to treat high blood pressure for the rest
of your life.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how med-
icine affects you. Don't work around dangerous machinery. Don't
climb ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and reflexes,
such as antihistamines, tranquilizers, sedatives,
pain medicine, narcotics and mind-altering drugs.
Discontinuing:
Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
Others:
May mask hypoglycemia symptoms.
Hot weather and fever may cause dehydration and drop in blood
pressure. Dose may require temporary adjustment. Weigh daily and
report any unexpected weight decreases to your doctor.
May cause rise in uric acid, leading to gout.
May cause blood-sugar rise in diabetics.
POSSIBLE INTERACTION WITH OTHER DRUGS
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|
| Allopurinol |
Decreased allopurinol effect. |
| Antidepressants, |
Dangerous drop in |
| tricyclic (TCA, |
blood pressure. Avoid |
| see Drugs Glossary) |
combination unless under medical |
| |
supervision. |
| Antidiabetics |
Increased |
| (see Drugs Glossary) |
antidiabetic effect. |
| Antihistamines |
Decreased |
| (see Drugs Glossary) |
antihistamine effect. |
| Antihypertensives |
Increased antihypertensive |
| (see Drugs Glossary) |
effect. |
| Barbiturates |
Increased |
| (see Drugs Glossary) |
barbiturate effect. Dangerous |
| |
sedation. |
| Beta-adrenergic |
Increased |
| blockers (see |
antihypertensive effect. |
| Drugs Glossary) |
Dosages of both drugs may require |
| |
adjustments. |
| Bumetanide |
Increased diuretic effect. |
| Cholestyramine |
Decreased hydrochlorothiazide |
| |
effect. |
| Cortisone drugs |
Excessive potassium |
| (see Drugs Glossary) |
loss that causes dangerous heart |
| |
rhythms. |
| Digitalis |
Excessive potassium |
| preparations |
loss that causes |
| (see Drugs Glossary) |
dangerous heart rhythms. Can either |
| |
increase or decrease heart rate. |
| |
Improves irregular heartbeat. |
| Diuretics (thiazide, |
Increased effect of |
| see Drugs Glossary) |
other thiazide diuretics. |
| Ethacrynic acid |
Increased diuretic effect. |
| Furosemide |
Increased diuretic effect. |
| Guanfacine |
Increased effect of both drugs. |
| Hypoglycemics (oral, |
Decreased ability to |
| see Drugs Glossary) |
lower blood glucose. |
| Indapamide |
Increased diuretic effect. |
| Insulin |
Decreased ability to lower blood |
| |
glucose. |
| MAO inhibitors |
Increased hydrochlorothiazide |
| (see Drugs Glossary) |
effect. |
| Metolazone |
Increased diuretic effect. |
| Narcotics |
Increased |
| (see Drugs Glossary) |
narcotic effect. Dangerous |
| |
sedation. |
| Nitrates |
Excessive |
| (see Drugs Glossary) |
blood-pressure drop. |
| Non-steroidal |
Decreased |
| anti-inflammatory |
anti-inflammatory effect. |
| drugs (NSAIDs, |
| see Drugs Glossary) |
| Phenytoin |
Increased beta-adrenergic effect. |
| Potassium |
Decreased potassium |
| supplements (see |
effect. |
| Drugs Glossary) |
| Probenecid |
Decreased probenecid effect. |
| Quinidine |
Slows heart excessively. |
| Reserpine |
Increased reserpine effect. |
| |
Excessive sedation and depression. |
| Tocainide |
May worsen congestive heart |
| |
failure. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
May increase blood pressure. |
| Tobacco: |
May increase blood pressure and |
| |
make heart work harder. Avoid. |
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