TRIMETHOBENZAMIDE

Brand & Generic Names

Arrestin	Tegamide
Benzacot	Ticon
Bio-Gan	Tigan
Stemetic	Tiject-20
T-Gen	Triban
Tebamide	Tribenzagan

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? Yes
• Drug class: Antiemetic

Uses

Reduces nausea and vomiting.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid. If you can't swallow whole, open capsule and take with liquid or food.
Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger.

When to take:
When needed, no more often than label directs.

If you forget a dose:
Take when you remember. Wait as long as label directs for next dose.

What drug does:
Possibly blocks nerve impulses to brain's vomiting centers.

Time lapse before drug works:
20 to 40 minutes.

Don't take with:
Any prescription or non-prescription drugs without consulting doctor.

Overdose

SYMPTOMS:
Confusion, convulsions, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see Overdose section.

Common:

None expected.

Infrequent:

• Rash, blurred vision, low blood pressure.
• Dizziness, headache, drowsiness, diarrhea, muscle cramps, unusual tiredness.

Rare:

• Convulsions.
• Seizures, tremor, depression, sore throat, fever, repeated vomiting, back pain, jaundice, Parkinson* symptoms, neck spasms.

Warnings & Precautions

Don't take if:

• You are allergic to trimethobenzamide.
• You are allergic to local anesthetics and have suppository form.

Before you start, consult your doctor:
If you have reacted badly to antihistamines.

Over age 60:
More susceptible to low blood pressure and sedative effects of this drug.

Pregnancy:
No proven harm to unborn child. Avoid if possible. Consult doctor.

Breast-feeding:
No proven problems. Avoid if possible. Consult doctor.

Infants & children:

• Injectable form not recommended.
• Avoid during viral infections. Drug may contribute to Reye's syndrome.

Prolonged use:

• Damages blood-cell production of bone marrow.
• Causes Parkinson's-like symptoms of tremors, rigidity.

Skin & sunlight:
Possible sun sensitivity. Use caution.

Driving, piloting or hazardous work:

• Use disqualifies you for piloting aircraft.
• Don't drive until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.

Others:
No problems expected.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Antidepressants*	Increased sedative effect.
Antihistamines*	Increased sedative effect.
Barbiturates*	Increased effect of both drugs.
Belladonna	Increased effect of both drugs.
Cholinergics*	Increased effect of both drugs.
Clozapine	Toxic effect on the central nervous
	system.
Ethinamate	Dangerous increased effects of
	ethinamate. Avoid combining.
Fluoxetine	Increased depressant effects of
	both drugs.
Guanfacine	May increase depressant effects of
	either medicine.
Leucovorin	High alcohol content of leucovorin
	may cause adverse effects.
Methyprylon	May increase sedative effect to
	dangerous level. Avoid.
Mind-altering drugs*	Increased effect of mind-altering
	drug.
Nabilone	Greater depression of central
	nervous system.
Narcotics*	Increased sedative effect.
Phenothiazines*	Increased effect of both drugs.
Sedatives*	Increased sedative effect.
Sertraline	Increased depressive effects of
	both drugs.
Sleep inducers*	Increased effect of sleep inducer.
Tranquilizers*	Increased sedative effect.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Oversedation. Avoid.
Beverages:	None expected.
Cocaine:	None expected.
Foods:	None expected.
Marijuana:	Increased antinausea effect.
Tobacco:	None expected.