TRILOSTANE

Brand & Generic Names

Modrastane

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Antiadrenal

Uses

Temporary treatment of Cushing's syndrome until surgery on adrenals or radiation to pituitary gland can be performed.

Dosage & Usage Information

How to take:
Capsules--Swallow with liquid. If you can't swallow whole, open capsule and take with liquid or food. Instructions to take on empty stomach mean 1 hour before or 2 hours after eating.

When to take:
Follow doctor's instructions.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Decreases function of the adrenal cortex.

Time lapse before drug works:
8 hours.

Don't take with:
Any other medicines (including over-the-counter drugs such as cough and cold medicines, laxatives, antacids, diet pills, caffeine, nose drops or vitamins) without consulting your doctor.

Overdose

SYMPTOMS:
None expected.

WHAT TO DO:

Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects

Life-threatening:

None expected.

Common:

Diarrhea, abdominal pain.

Infrequent:

Muscle ache, bloating, watery eyes, nausea, increased salivation, flushing, burning mouth or nose.

Rare:

Darkening skin, tiredness, appetite loss, depression, skin rash, vomiting.

Warnings & Precautions

Don't take if:
You know you are allergic to trilostane.

Before you start, consult your doctor:

• If you have an infection.
• If you will have surgery while taking.
• If you have a head injury.
• If you have kidney disease.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. You may need smaller doses for shorter periods of time.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Safety not established. Consult doctor.

Infants & children:
Effect not documented. Consult your pediatrician.

Prolonged use:

• Not intended for prolonged use.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check serum electrolytes and urinary 17 - hydroxycorticosteroid.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel confused, drowsy or dizzy.

Discontinuing:
No special problems expected.

Others:

• Advise any doctor or dentist whom you consult that you take this medicine.
• May affect results in some medical tests.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Aminoglutethimide	Too much decrease in adrenal
	function.
Mitotane	Too much decrease in adrenal
	function.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	No special problems expected.
Beverages:	No special problems expected.
Cocaine:	No special problems expected.
Foods:	No special problems expected.
Marijuana:	No special problems expected.
Tobacco:	No special problems expected.