Brand & Generic Names
Navane |
|
Thiothixene HCI Intensol |
|
Basic Information
- Habit forming? No
- Prescription needed? Yes
- Available as generic? No
- Drug class: Tranquilizer (thioxanthine), antiemetic
Uses
- Reduces anxiety, agitation, psychosis.
- Stops vomiting, hiccups.
Dosage & Usage Information
How to take:
Capsule--Swallow with liquid. If you can't swallow whole, open
capsule and take with liquid or food.
Syrup--Dilute dose in beverage before swallowing.
When to take:
At the same time each day.
If you forget a dose:
Take as soon as you remember up to 2 hours
late. If more than 2 hours, wait for next scheduled dose (don't
double this dose).
What drug does:
Corrects imbalance of nerve impulses.
Time lapse before drug works:
3 weeks.
Don't take with:
Any other medicine without consulting your doctor or pharmacist.
Overdose
SYMPTOMS:
Drowsiness, dizziness, weakness, muscle rigidity,
twitching, tremors, confusion, dry mouth, blurred vision, rapid
pulse, shallow breathing, low blood pressure, convulsions, coma.
WHAT TO DO:
- Dial 911 (emergency) or O (operator) for an ambulance or
medical help. Then give first aid immediately.
- If patient is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make patient
vomit. If you can't get help quickly, take patient to nearest
emergency facility.
- See EMERGENCY Information.
Possible Adverse Reactions or Side Effects
Life-threatening:
Uncontrolled muscle Discontinue. Seek
movements of tongue, emergency treatment.
face and other muscles
(neuroleptic malignant
syndrome*, rare).
Common:
- Fainting, jerky
and involuntary
movements, blurred
vision, restlessness,
rapid heartbeat.
- Dizziness,
drowsiness,
constipation, muscle
spasms, shuffling walk,
decreased sweating,
increased appetite,
weight gain, sensitivity
to light.
- Dry mouth, nasal
congestion.
Infrequent:
- Rash, abdominal
pain.
- Less sexual ability,
difficult urination.
- Menstrual irregularities,
swollen breasts, milk
secretion by breasts.
Rare:
Sore throat, fever,
jaundice, lip smacking,
cheek puffing, chewing
movements of mouth,
heatstroke, bleeding
or bruising.
Warnings & Precautions
Don't take if:
- You are allergic to any thioxanthine or phenothiazine
tranquilizer.
- You have serious blood disorder.
- You have Parkinson's disease.
- Patient is younger than 12.
Before you start, consult your doctor:
- If you have had liver or kidney disease.
- If you have epilepsy, glaucoma, prostate trouble.
- If you have high blood pressure or heart disease (especially
angina).
- If you use alcohol daily.
- If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons.
Pregnancy:
Safety not established. Decide with your doctor whether drug benefits justify risk to unborn child.
Breast-feeding:
Studies inconclusive. Consult your doctor.
Infants & children:
Not recommended.
Prolonged use:
- Pigment deposits in lens and retina of eye.
- Involuntary movements of jaws, lips, tongue (tardive
dyskinesia).
- Talk to your doctor about the need for follow-up medical
examinations or laboratory studies to check complete blood
counts (white blood cell count, platelet count, red blood cell
count, hemoglobin, hematocrit), liver function, eyes.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp.
Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you drink
alcohol or take medicine affecting alertness and reflexes.
Discontinuing:
Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
Others:
Hot temperatures increase chance of heat stroke.
Possible Interaction with Other Drugs
GENERIC NAME |
COMBINED EFFECT |
| |
------------------------ |
----------------------- |
Anticholinergics* |
Increased anticholinergic effect. |
Anticonvulsants* |
Change in seizure pattern. |
Antidepressants, |
Increased thiothixene effect. |
tricyclic (TCA)* |
Excessive sedation. |
Antihistamines* |
Increased thiothixene effect. |
|
Excessive sedation. |
Antihypertensives* |
Excessively low blood pressure. |
Barbiturates* |
Increased thiothixene effect. |
|
Excessive sedation. |
Bethanechol |
Decreased bethanechol effect. |
Bupropion |
Increased risk of major seizures. |
Dronabinol |
Increased effects of both drugs. |
|
Avoid. |
Epinephrine |
Excessively low blood pressure. |
Guanethidine |
Decreased guanethidine effect. |
Levodopa |
Decreased levodopa effect. |
MAO inhibitors* |
Excessive sedation. |
Mind-altering drugs* |
Increased thiothixene effect. |
|
Excessive sedation. |
Narcotics* |
Increased thiothixene effect. |
|
Excessive sedation. |
Pergolide |
Decreased pergolide effect. |
Procarbazine |
Increased sedation. |
Sedatives* |
Increased thiothixene effect. |
|
Excessive sedation. |
Sertraline |
Increased depressive effects |
|
of both drugs. |
Sleep inducers* |
Increased thiothixene effect. |
|
Excessive sedation. |
Tranquilizers* |
Increased thiothixene effect. |
|
Excessive sedation. |
Possible Interaction with Other Substances
INTERACTS WITH |
COMBINED EFFECT |
--------------- |
--------------- |
Alcohol: |
Excessive brain depression. Avoid. |
| |
Beverages: |
None expected. |
| |
Cocaine: |
Decreased thiothixene effect. |
|
Avoid. |
| |
Foods: |
None expected. |
| |
Marijuana: |
Daily use--Fainting likely, |
|
possible psychosis. |
| |
Tobacco: |
None expected. |
|