ANTI-INFLAMMATORY DRUGS, NON-STEROIDAL (NSAIDs)

Brand & Generic Names

Aches-N-Pain	INDOMETHACIN
Advil	Intrabutazone
Advil Caplets	KETOPROFEN
Albert Tiafen	Lidifen
Alka-Butazolidin	Lodine
Alka-Phenylbutazone	Meclofen
Alkabutazone	MECLOFENAMATE
Alrheumat	Meclomen
Amersol	Medipren
Anaprox	MEFENAMIC ACID
Anaprox DS	Midol 200
Ansaid	Midol-IB
Apo-Diclo	Motrin
Apo-Flurbiprofen	Motrin-IB
Apo-Ibuprofen	Motrin-IB Caplets
Apo-Indomethacin	Motrin, Children's
Apo-Keto	NABUMETONE
Apo-Keto-E	Nalfon
Apo-Naproxen	Nalfon 200
Apo-Piroxicam	Naprosyn
Apsifen	NAPROXEN
Apsifen-F	Naxen
Bayer Select Pain Relief	Novo-Keto-EC
Formula Caplets	Novo-Sundac
Brufen	Novobutazone
Butacote	Novomethacin
Butazone	Novonaprox
Children's Advil	Novopirocam
Clinoril	Novoprofen
CoAdvil	Nu-Indo
Cotybutazone	Nu-Pirox
Cramp End	Nuprin
DICLOFENAC	Nuprin Caplets
DIFLUNISAL	Orudis
Dolgesic	Orudis-E
Dolobid	Oruvail
ETODOLAC	Pamprin-IB
Excedrin-IB Caplets	Paxofen
Excedrin-IB Tablets	Pedia
Feldene	Profen
FENOPROFEN	PHENYLBUTAZONE
Fenopron	Phenylone Plus
FLOCTAFENINE	Ponstan
FLURBIPROFEN	Ponstel
Froben	PIROXICAM
Genpril	Profen
Haltran	Progesic
Ibifon-600 Caplets	Relafen
Ibren	Rhodis-EC
Ibu	Ro-Profen
Ibu-4	Rufen
Ibu-6	Saleto-200
Ibu-8	Saleto-400
Ibu-200	Saleto-600
Ibumed	Saleto-800
Ibuprin	SULINDAC
Ibupro-600	Surgam
IBUPROFEN	Synflex
Ibutex	Telectin DS
Idarac	TENOXICAM
Ifen	TIAPROFENIC ACID
Imbrilon	TOLMETIN
Indameth	Trendar
Indocid	Voltaren
Indocid SR	Voltaren SR
Indocin	Voltarol
Indocin SR	Voltarol Retard
Indolar SR

Basic Information

• Habit forming? No
• Prescription needed? Yes, for some.
• Available as generic? Yes, for some.
• Drug class: Anti-inflammatory (non-steroidal)

Uses

• Treatment for joint pain, stiffness, inflammation and swelling of arthritis and gout.
• Pain reliever.
• Treatment for dysmenorrhea (painful or difficult menstruation).
• Treats juvenile rheumatoid arthritis.

Dosage & Usage Information

How to take:
Tablet or capsule--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. Don't crumble delayed release tablet.
Liquid--Take as directed on bottle. Don't freeze.
Rectal suppositories--Remove wrapper and moisten suppository with water. Gently insert into rectum, large end first. If suppository is too soft, chill in refrigerator or cool water before removing wrapper.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Reduces tissue concentration of prostaglandins (hormones which produce inflammation and pain).

Time lapse before drug works:
Begins in 4 to 24 hours. May require 3 weeks regular use for maximum benefit.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Confusion, agitation, severe headache, incoherence, convulsions, possible hemorrhage from stomach or intestine, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• See EMERGENCY information.

Possible Adverse Reactions or Side Effects

Life-threatening:

Hives, rash, intense Seek emergency treatment immediately. itching, faintness soon after a dose (anaphylaxis in aspirin-sensitive persons).

Common:

• Dizziness, nausea, pain.
• Headache.

Infrequent:

• Depression; drowsiness; ringing in ears; swollen feet, face or legs; consti- pation or diarrhea; vomiting; gaseousness; dry mouth; tremors; insomnia.
• Muscle cramps, numb- ness or tingling in hands or feet, mouth ulcers, rapid weight gain.

Rare:

• Convulsions; confusion; rash, hives or itch; blurred vision; black, bloody, tarry stool; difficult breathing; tightness in chest; rapid heart- beat; unusual bleeding or bruising; blood in urine; jaundice; psychosis; frequent, painful urination; fainting; sore throat; fever; chills; diminished hearing; eye pain; nose- bleeds; severe abdominal pain.
• Fatigue, weakness, menstrual irregularities.

Warnings & Precautions

Don't take if:

• You are allergic to aspirin or any non-steroidal, anti-inflammatory drug.
• You have gastritis, peptic ulcer, enteritis, ileitis, ulcerative colitis, asthma, heart failure, high blood pressure or bleeding problems.
• Patient is younger than 15.

Before you start, consult your doctor:

• If you have epilepsy.
• If you have Parkinson's disease.
• If you have been mentally ill.
• If you have impaired kidney or liver function.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Studies inconclusive on harm to unborn child. Decide with your doctor whether drug benefits justify risk to unborn child.

Breast-feeding:
May harm child. Avoid.

Infants & children:
Not recommended for anyone younger than 15. Use only under medical supervision.

Prolonged use:

• Eye damage.
• Reduced hearing.
• Sore throat, fever.
• Weight gain.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), liver function, stools for blood, eyes.

Skin & sunlight:
Possible increased sensitivity to sunlight.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:
Don't discontinue without consulting your doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

Others:
Advise any doctor or dentist whom you consult that you take this medicine.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
-------------------------	-----------------------
ACE inhibitors*:	May decrease ACE inhibitor effect.
Antacids*	Decreased pain relief.
Anticoagulants*, oral	Increased risk of bleeding.
Anticonvulsants,	Increased anticonvulsant effect.
Anti-inflammatory	Danger of increased side effects, such
pain relievers (any	as stomach bleeding.
Aspirin	Increased risk of stomach ulcer.
Beta-adrenergic	Decreased antihypertensive effect.
Carteolol	Decreased antihypertensive effect of
	carteolol.
Cephalosporins*	Increased risk of bleeding.
Cortisone drugs*	Increased risk of stomach ulcer.
Didanosine	Increased risk of pancreatitis
	(sulindac only).
Diuretics*	May decrease diuretic effect.
Gold compounds*	Increased risk of kidney toxicity.
Lithium	Increased lithium effect.
Methotrexate	Increased risk of methotrexate.
Minoxidil	Decreased minoxidil effect.
Probenecid	Increased pain relief.
Sotalol	Decreased antihypertensive effect of
	sotalol.
Terazosin	Decreases effectiveness of terazosin.
	Causes sodium and fluid retention.
Thyroid hormones*	Rapid heartbeat, blood pressure rise.
Tiopronin	Increased risk of toxicity to kidneys.
Triamterene	Reduced triamterene effect.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Possible stomach ulcer or bleeding.
Beverages:	None expected.
Cocaine:	None expected.
Foods:	None expected.
Marijuana:	Increased pain relief from NSAIDs.
Tobacco:	None expected.