OXTRIPHYLLINE & GUAIFENESIN

Brand & Generic Names

Brondecon

Brondelate

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Bronchodilator (xanthine), cough/cold preparation

Uses

• Treatment for bronchial asthma symptoms.
• Loosens mucus in respiratory passages from allergies and infections.

Dosage & Usage Information

How to take:
Tablet or elixir--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
Most effective taken on empty stomach 1 hour before or 2 hours after eating. However, may take with food to lessen stomach upset.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Relaxes and expands bronchial tubes.
Increases production of watery fluids to thin mucus so it can be coughed out or absorbed.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Any stimulant.
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Restlessness, irritability, confusion, delirium, convulsions, rapid pulse, nausea, vomiting, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

Difficult breathing, Discontinue. Seek irregular or fast emergency treatment. heartbeat.

Common:

Headache, irritability, nervousness, restlessness, insomnia, nausea, vomiting, abdominal pain, drowsiness.

Infrequent:

• Hives, rash, red or flushed face, diarrhea, heartburn, muscle twitching.
• Dizziness, lightheadedness, appetite loss.

Rare:

None expected.

Warnings & Precautions

Don't take if:

• You are allergic to any cough or cold preparation containing guaifenesin or any bronchodilator.
• You have an active peptic ulcer.

Before you start, consult your doctor:

• If you have had impaired kidney or liver function.
• If you have gastritis, peptic ulcer, high blood pressure or heart disease.
• If you take medication for gout.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. For drug to work, you must drink 8 to 10 glasses of fluid per day.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:

• Stomach irritation.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check serum oxtriphylline levels, lung function.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if lightheaded or dizzy. Otherwise, no problems expected.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.

Others:
No problems expected.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Allopurinol	Decreased allopurinol effect.
Anticoagulants*	Possible risk of bleeding.
Ephedrine	Increased effect of both drugs.
Epinephrine	Increased effect of both drugs.
Erythromycins*	Increased bronchodilator effect.
Furosemide	Increased furosemide effect.
Lincomycins*	Increased bronchodilator effect.
Lithium	Decreased lithium effect.
Probenecid	Decreased effect of both drugs.
Propranolol	Decreased bronchodilator effect.
Rauwolfia alkaloids*	Rapid heartbeat.
Sulfinpyrazone	Decreased sulfinpyrazone effect.
Troleandomycin	Increased bronchodilator effect.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	None expected.
Caffeine drinks.	Nervousness and insomnia. You must
	drink 8 to 10 glasses of fluid per
	day for drug to work.
Cocaine:	Excess stimulation. Avoid.
Foods:	None expected.
Marijuana:	Slightly increased antiasthmatic
	effect of bronchodilator.
Tobacco:	Decreased bronchodilator effect and
	harmful for all conditions
	requiring bronchodilator treatment.
	Avoid.