INDAPAMIDE

Brand & Generic Names

Lozide

Lozol

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Antihypertensive, diuretic

Uses

• Controls, but doesn't cure, high blood pressure.
• Reduces fluid retention (edema) caused by conditions such as heart disorders.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
At the same times each day, usually at bedtime.

If you forget a dose:
Bedtime dose--If you forget your once-a- day bedtime dose, don't take it more than 3 hours late. Never double dose.

What drug does:
Forces kidney to excrete more sodium and causes excess salt and fluid to be excreted.

Time lapse before drug works:
2 hours for effect to begin. May require 1 to 4 weeks for full effects.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Nausea, vomiting, diarrhea, very dry mouth, thirst, weakness, excessive fatigue, very rapid heart rate, weak pulse.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see Overdose section.

Common:

• Excessive tiredness or weakness, muscle cramps.
• Frequent urination.

Infrequent:

Insomnia, mood change, dizziness on changing position, headache, excessive thirst, diarrhea, appetite loss, nausea, dry mouth, decreased sex drive.

Rare:

• Weak pulse.
• Itching, rash, hives, irregular heartbeat.

Warnings & Precautions

Don't take if:

• You are allergic to indapamide or to any sulfa drug or thiazide diuretic*.
• You have severe kidney disease.

Before you start, consult your doctor:

• If you have severe kidney disease.
• If you have diabetes.
• If you have gout.
• If you have liver disease.
• If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.
• If you have lupus erythematosus.
• If you are pregnant or plan to become pregnant.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Unknown effect on child. Consult doctor.

Infants & children:
Use only under close medical supervision.

Prolonged use:
Request laboratory studies for blood sugar, BUN, uric acid and serum electrolytes (potassium and sodium).

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:
Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

Others:
No problems expected.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
ACE inhibitors*:	Decreased blood
captopril, enalapril,	pressure. Possible
lisinopril	excessive potassium in blood.
Allopurinol	Decreased allopurinol effect.
Amiodarone	Increased risk of heartbeat
	irregularity due to low potassium.
Amphotericin B	Increased potassium.
Antidepressants,	Dangerous drop in
tricyclic (TCA)*	blood pressure.
Antidiabetic agents,	Increased blood sugar.
Antihypertensives,	Increased anti-
other*	hypertensive effect.
Barbiturates*	Increased indapamide effect.
Beta-adrenergic	Increased effect of
blockers*	indapamide.
Calcium supplements*	Increased calcium in blood.
Carteolol	Increased antihypertensive effect.
Cholestyramine	Decreased indapamide effect.
Colestipol	Decreased indapamide effect.
Cortisone drugs*	Excessive potassium loss that may
	cause dangerous heart rhythms.
Digitalis	Excessive potassium
preparations*	loss that may cause dangerous heart
	rhythms.
Diuretics, thiazide*	Increased effect of thiazide
	diuretics.
Indomethacin	Decreased indapamide effect.
Lithium	High risk of lithium toxicity.
MAO inhibitors*	Increased indapamide effect.
Nicardipine	Dangerous blood pressure drop.
	Dosages may require adjustment.
Nimodipine	Dangerous blood pressure drop.
Opiates*	Weakness and faintness when arising
	from bed or chair.
Probenecid	Decreased probenecid effect.
Sotalol	Increased antihypertensive effect.
Terazosin	Decreased effectiveness of
	terazosin.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Dangerous blood pressure drop.
	Avoid.
Beverages:	No problems expected.
Cocaine:	Increased risk of heart block and
	high blood pressure.
Licorice.	Excessive potassium loss that may
	cause dangerous heart rhythms.
Marijuana:	Reduced effectiveness of
	indapamide. Avoid.
Tobacco:	Reduced effectiveness of
	indapamide. Avoid.