General Information
DEFINITION--Sudden failure of the kidneys to function. Kidneys normally help rid
the body of waste products, and when they fail, the waste products build up and cause
symptoms that vary in severity. This usually has a short, relatively severe course, but
often is curable.
BODY PARTS INVOLVED--Kidneys.
SEX OR AGE MOST AFFECTED--Both sexes; all ages.
SIGNS & SYMPTOMS
Early stages:
- Little or no urine output.
Later stages:
- Nausea, vomiting, diarrhea and appetite loss.
- Mental changes, including irritability, drowsiness, stupor or coma.
- Convulsions.
- Severe itching.
- High or low blood pressure.
- Unexplained bruising, bleeding spots under the skin or spontaneous bleeding. The
symptoms of the underlying cause (see list below) will also be present.
CAUSES--
Conditions in the kidney, or in other areas of the body, that cause the kidneys to stop
functioning. This leads to a buildup of waste products in the blood and tissues.
Underlying conditions include:
- Shock with very low blood pressure.
- Blood poisoning (septicemia).
- Congestive heart failure.
- Fluid and electrolyte imbalance.
- Blood-transfusion reaction.
- Severe accident with extensive muscle injury.
- Acute glomerulonephritis.
- Multiple myeloma.
- Obstruction of blood vessels that supply the kidney.
- Kidney stones that obstruct both ureters or the urethra.
- Prostate enlargement.
- Use of certain medications, including anticancer drugs, kanamycin, amphotericin B,
anticonvulsants or excessive vitamin D.
- Overdose of many poisons or drugs, especially mind-altering drugs.
RISK INCREASES WITH
- Persons with one kidney.
- Recent surgery.
- Accidents with severe injuries.
- Medical history of conditions affecting the kidney, such as diabetes or gout.
HOW TO PREVENT--No specific preventive measures. Avoid causes and risk factors
when possible.
What To Expect
DIAGNOSTIC MEASURES--
- Medical history and exam by a doctor.
- Laboratory blood counts and blood and urine tests that measure kidney function and fluid
and electrolyte balance.
- ECG (See Glossary).
- Needle biopsy (See Glossary) of kidneys.
- X-rays of the abdomen, kidneys, ureters and bladder to detect kidney stones.
APPROPRIATE HEALTH CARE
- Doctor's treatment.
- Surgery, if surgery can correct cause.
- Hospitalization for fluid and electrolyte therapy and kidney dialysis (sometimes).
- Dialysis (See Glossary) may be required until the kidneys
recover function.
POSSIBLE COMPLICATIONS
- Congestive heart failure.
- Increased risk of infections.
- Chronic kidney failure.
PROBABLE OUTCOME--If the underlying condition can be controlled and the kidney
failure can be treated promptly, complete recovery is likely. If not, the disorder can
lead to chronic kidney failure or death.
How To Treat
GENERAL MEASURES--
- Follow your doctor's instructions. Compliance with your medical treatment plan is
essential.
- See Resources for Additional Information.
MEDICATION--Your doctor may prescribe:
- Medications appropriate to control the underlying condition.
- Antibiotics if infection develops.
ACTIVITY--Rest in bed until the condition is cured. Then resume your normal
activities as soon as symptoms improve.
DIET--Food and water intake is rigorously controlled to prevent fluid and
electrolyte imbalance, and to minimize buildup of body wastes. A diet high in
carbohydrates and low in protein (main source of waste products) to reduce workload for
kidneys may be part of the treatment.
Call Your Doctor If
The following occurs during treatment: Chills, fever, headache or muscle aches.
Shortness or breath. Unexpected bleeding from any body opening.
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